PedsEndoPhilly said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.
PharmD_Rodriguez said:Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body.
This is exactly what I could not find anywhere else.
PedsEndoPhilly said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
I read this differently from PedsEndoPhilly, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
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Shop Reference StandardsOne concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.