FDA_TrackerJim said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
FDA_TrackerJim said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.
Adding the clinical framing, because it changes how the question reads.
DEXA scan update relevant to lean mass:
Scanned at months 0, 6, and 12. Here are the body comp numbers:
| Baseline | Month 6 | Month 12 | |
|---|---|---|---|
| Total mass | 258 lbs | 223 lbs | 195 lbs |
| Fat mass | 98 lbs | 78 lbs | 45 lbs |
| Lean mass | 151 lbs | 153 lbs | 152 lbs |
| Body fat % | 43% | 33% | 24% |
Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.
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Browse GL BiochemEndoResFellow said:DEXA scan update relevant to lean mass: Scanned at months 0, 6, and 12.
Can confirm. Same sequence, different timescale.
EndoResFellow said:DEXA scan update relevant to lean mass: Scanned at months 0, 6, and 12.
Coming at EndoResFellow’s question from a different direction. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.