DebRD_ATL said:Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 258 | 253 | 228 | 203 |
| A1C (%) | 6.8 | 6.8 | 5.5 | 5.5 |
| hsCRP (mg/L) | 8.0 | 3.0 | 1.5 | 1.4 |
| Triglycerides | 238 | 148 | 118 | 108 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/week, protein 1.4g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
A narrower follow-up, since the general answer is now clear:
How long did you give it before you decided it was working?
quinn_sf said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 258 253 228 203 A1C (%) 6.8 6.8 5.5…
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
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Browse GL Biochemquinn_sf said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 258 253 228 203 A1C (%) 6.8 6.8 5.5…
DEXA scan update relevant to lean mass:
Scanned at months 0, 6, and 12. Here are the body comp numbers:
| Baseline | Month 6 | Month 12 | |
|---|---|---|---|
| Total mass | 263 lbs | 228 lbs | 210 lbs |
| Fat mass | 113 lbs | 83 lbs | 45 lbs |
| Lean mass | 151 lbs | 150 lbs | 157 lbs |
| Body fat % | 40% | 30% | 24% |
Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.
quinn_sf said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 258 253 228 203 A1C (%) 6.8 6.8 5.5…
This is exactly what I could not find anywhere else.