Dr.EM_Chicago said:Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
Clinical perspective, offered as context rather than as advice. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.
CarlaRPh_TPA said:Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…
Pushing back on CarlaRPh_TPA here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
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Shop Reference StandardsAdding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.