anna.melb_AU said:lean mass + resistance training is the combo.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 254 | 234 | 214 | 209 |
| A1C (%) | 6.9 | 6.4 | 5.9 | 5.6 |
| hsCRP (mg/L) | 9.0 | 4.0 | 1.5 | 1.0 |
| Triglycerides | 184 | 154 | 114 | 94 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/week, protein 1.4g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
Following on from anna.melb_AU — and this may be the naive question:
Did your prescriber agree with that reading, and if not what was their objection?
Dr.PathRoch said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 254 234 214 209 A1C (%) 6.9 6.4 5.9…
Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Lumbar spine T-score: -0.8 → -0.6 (stable to slightly improved)
Femoral neck T-score: -0.13 → -0.7 (stable)
No significant bone loss despite 60 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.
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Shop Reference StandardsDr.PathRoch said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 254 234 214 209 A1C (%) 6.9 6.4 5.9…
Regarding lean mass: I accidentally injected my dose intramuscularly instead of subcutaneously last week (went in at wrong angle, too deep). Called my pharmacist — they said it's not dangerous but may absorb faster, potentially causing more GI effects.
Sure enough, had worse nausea that day. Lesson learned: pinch the skin properly and use the right needle length for your body composition.
Dr.PathRoch said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 254 234 214 209 A1C (%) 6.9 6.4 5.9…
Saving this. It is the first explanation that did not require me to already understand it.