DeniseRN_TPA said:The liver data is among the strongest non-weight findings in the class.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
marcus_mpls said:Steady state is the thing most people miss.
That reframing is the part I needed. I will report back once I have actually tried it.
DeniseRN_TPA said:The liver data is among the strongest non-weight findings in the class.
Pushing back on DeniseRN_TPA here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsOne concrete data point for the thread. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.
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