chris_chi24 said:It helps to ask what evidence would change your mind before you look at any.
True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.
Ask again with the specifics and you will get a better answer than this one.
oliver_london said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
chris_chi24 said:It helps to ask what evidence would change your mind before you look at any.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
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Browse GL BiochemOne concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.