MASHdoc_SA said:It is worth asking what the claim would look like if it were false.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
KevinCompounds said:Agreed, and hsCRP is worth reading alongside them.
Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.
MASHdoc_SA said:It is worth asking what the claim would look like if it were false.
Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.
Happy to go further on any of that.
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Shop Reference StandardsAdding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.