My prescriber wanted a baseline TSH and did not want a calcitonin, and I would like to understand the reasoning rather than just accepting it.
What would genuinely help is knowing why calcitonin screening is not recommended when the label carries a thyroid warning, because those two facts look contradictory from the outside.
I have searched first, so if this is covered somewhere point me at it and I will read it.
fiona_VT said:My prescriber wanted a baseline TSH and did not want a calcitonin, and I would like to understand the reasoning rather than just accepting it.
Thyroid cancer screening labs for thyroid monitoring — addressing the boxed warning concern with actual data:
Calcitonin level: 3.0 pg/mL (normal <10). Checked at baseline, month 6, and month 12. Rock stable, no upward trend.
Thyroid ultrasound: normal, no nodules at month 12.
The MTC risk from rodent studies has not been confirmed in human post-marketing data across millions of patient-years. The boxed warning is a regulatory precaution based on animal data. While monitoring is prudent, the clinical risk appears to be negligible.
TirzTom said:Thyroid cancer screening labs for thyroid monitoring — addressing the boxed warning concern with actual data: Calcitonin level: 3.0 pg/mL (normal…
Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.
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Shop Reference Standardsfiona_VT said:My prescriber wanted a baseline TSH and did not want a calcitonin, and I would like to understand the reasoning rather than just accepting it.
This is my experience too, for whatever a second data point is worth.
Clinical perspective, offered as context rather than as advice. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.