Reading the retatrutide phase 2 data properly rather than the headline, and the 24% figure is doing a lot of work that the confidence interval does not support as firmly as people think.
For anyone tracking the class: GLP-1 alone gets you appetite, GLP-1 plus GIP adds tolerability and lipid handling, and adding glucagon adds expenditure and liver-fat reduction. Each addition also adds a receptor system that can generate side effects.
What would genuinely help is knowing what the phase 2 dropout pattern implies about how the phase 3 tolerability will read.
Practical detail welcome, however dull — the duller the better.
Taking the question as asked, rather than the general version of it. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
Correct me if the detail matters more than I have assumed.
BethLabQueen said:The version of this that has an answer is narrower than the version being asked.
That is correct as far as it goes, and here is where it stops going. The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study. A curve that has not flattened is a real finding, but it also means the true plateau is unknown, and phase 2 populations are small and selected.
That is the short version; the long version is somebody else's post.
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Browse GL Biochemfiona_glasgow said:Reading the retatrutide phase 2 data properly rather than the headline, and the 24% figure is doing a lot of work that the confidence interval does…
Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.
From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
Correct me if the detail matters more than I have assumed.