dan_philly said:SELECT is the trial that changed the framing of this class, because it was an outcome trial rather than a weight trial: about a 20% relative reduction…
Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off amlodipine entirely! My cardiologist is thrilled.
If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.
One thing that is still open after hyun_seoul’s answer:
Was that from a primary source or from a summary of one?
Dr.AddMedPHL said:Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off amlodipine entirely!
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:
Weight: consistent downtrend, -1.5 lbs/week average
Fasting glucose (finger stick): stable at 86 mg/dL
Blood pressure (home): 115/72 average
Resting heart rate: 66 bpm (down from 82)
Waist circumference: down 16 inches total
The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.
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Browse GL BiochemDr.AddMedPHL said:Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off amlodipine entirely!
Cardiac biomarkers and cardiovascular risk: my cardiologist ordered advanced cardiac labs given my family history. Results were encouraging:
- NT-proBNP: 45 pg/mL (normal, cardiac function preserved)
- Lp(a): 25 nmol/L (genetic, unchanged — expected)
- ApoB: dropped from 155 to 85 mg/dL (excellent response)
- Coronary calcium score: 0 (unchanged from baseline — reassuring)
The ApoB reduction is particularly meaningful — it's considered the best single predictor of cardiovascular risk. GLP-1 therapy seems to improve this consistently.
DeniseRN_TPA said:Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…
Senior perspective on cardiovascular risk: I'm 63 years old and started this journey skeptically. My geriatrician recommended it after years of failed interventions.
9 months later: down 41 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.
To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.