TrialNerd_Beth said:The mechanism and the magnitude are separate questions.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
MikeFit_NJ said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
That reframing is the part I needed. Adding it to my notes with a link back to this thread.
TrialNerd_Beth said:The mechanism and the magnitude are separate questions.
I read this differently from TrialNerd_Beth, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
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Correct me if the detail matters more than I have assumed.