DebRD_ATL said:Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of people never reach the dose the headline number came from.
josh_phd_bmore said:Agreed, and it is worth saying that rounding to the nearest whole unit is usually acceptable at maintenance doses and is not acceptable at the bottom…
This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.
DebRD_ATL said:Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.
I read this differently from DebRD_ATL, on substance rather than tone. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.
That is the short version; the long version is somebody else's post.
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Browse GL BiochemNicoleRaleigh said:I reconstituted a 10mg vial with 2ml of bacteriostatic water and I want someone to check my unit arithmetic before I draw anything, because I keep…
For anyone reconstituting dosing arithmetic peptides: the water-to-powder ratio determines your concentration. Here's my reference:
| Vial Size | BAC Water | Concentration | 0.25mg Dose |
|---|---|---|---|
| 5mg | 2mL | 2.5mg/mL | 10 units |
| 5mg | 2.5mL | 2mg/mL | 12.5 units |
| 10mg | 2mL | 5mg/mL | 5 units |
| 10mg | 3mL | 3.33mg/mL | 7.5 units |
More water = easier to measure small doses but vial runs out faster. Find the balance that works for your dose.
Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.