Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
What I am trying to establish is how much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical.
I have searched first, so if this is covered somewhere point me at it and I will read it.
oliver_london said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
Senior perspective on cardiovascular risk: I'm 66 years old and started this journey skeptically. My cardiologist recommended it after years of failed interventions.
14 months later: down 39 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.
To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.
RetaRick_CA said:Senior perspective on cardiovascular risk: I'm 66 years old and started this journey skeptically.
I'm 67 years old and want to share my perspective on cardiovascular risk as an older member of this community.
My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.
17 months later: down 64 lbs, off atorvastatin, A1C from 8.8% to 5.3%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.
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Browse GL Biochemoliver_london said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
Can confirm. Same sequence, different timescale.
Clinical perspective, offered as context rather than as advice.
Cardiac biomarkers and cardiovascular risk: my cardiologist ordered advanced cardiac labs given my family history. Results were encouraging:
- NT-proBNP: 52 pg/mL (normal, cardiac function preserved)
- Lp(a): 32 nmol/L (genetic, unchanged — expected)
- ApoB: dropped from 137 to 92 mg/dL (excellent response)
- Coronary calcium score: 0 (unchanged from baseline — reassuring)
The ApoB reduction is particularly meaningful — it's considered the best single predictor of cardiovascular risk. GLP-1 therapy seems to improve this consistently.