Adding the numbers, since they settle part of this. Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with published data behind them are 5, 10 and 15mg.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Following on from sarah_TO — and this may be the naive question:
Whether anyone has held 10mg long term rather than climbing, and what happened over the following year?
lisa_labSD said:Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with…
Coming at lisa_labSD’s question from a different direction. Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five. That matters when you are deciding whether a dose step has finished expressing itself.
That is the short version; the long version is somebody else's post.
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Update: the eight-week restart pattern people described is exactly what happened. I nearly abandoned it at week five.
DebRD_ATL said:Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.
Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg. It is still the best direct evidence available, but it is not the comparison most people think they are citing.