Dr.PainCLE said:Orforglipron is the more interesting oral story because it is not a peptide at all.
I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.
The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.
I would rather be corrected than agreed with, if it comes to it.
julia.endo said:I do not accept that the fasting window is a minor inconvenience.
There is a second half to this that has not been said yet. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
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Shop Reference StandardsOne thing that is still open after KetoKyle’s answer:
How much of the oral variability is the SNAC absorption window and how much is dose, because the two get conflated constantly?
Reporting back.
Follow-up: moving the tablet to the moment I wake, before anything else, was the whole fix. The dose never changed.