Dr.MetabolicMD said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Agreeing with Dr.MetabolicMD, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.
pam_stl said:The mechanism is more central than most summaries suggest.
Thank you — that is the clearest version of this I have read, and I have read a lot of them.
Dr.MetabolicMD said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.
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Browse GL BiochemAdding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
Happy to go further on any of that.
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