I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
What I am trying to establish is what the pharmacokinetic argument against splitting a weekly dose actually is, since intuitively it should smooth the curve.
Practical detail welcome, however dull — the duller the better.
DanielChem_CHI said:I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
Dose splitting update on split dosing: instead of 2.4mg once weekly, I've been doing 1.2mg twice weekly (Mon/Thu) with my doctor's approval. The appetite suppression is more consistent and side effects are noticeably milder.
Not medical advice, just sharing what's worked for me. Discuss with your provider before trying this.
Dr.SurgeonPGH said:Dose splitting update on split dosing: instead of 2.4mg once weekly, I've been doing 1.2mg twice weekly (Mon/Thu) with my doctor's approval.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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Browse GL BiochemDanielChem_CHI said:I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
Same pattern here, and in the same order.
Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.