DebRD_ATL said:Start from the measurement rather than the conclusion.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
Dr.SurgeonPGH said:Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…
This is exactly what I could not find anywhere else.
DebRD_ATL said:Start from the measurement rather than the conclusion.
This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
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Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.