From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Worth separating that from the titration schedule, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
PeptideChemSF said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
This is my experience too, for whatever a second data point is worth.
PeptideChemSF said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
There is a second half to this that has not been said yet. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
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Browse GL BiochemFound this through search years later and it is still the best discussion of the question, so adding one thing. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.
I would rather be corrected than agreed with, if it comes to it.
Following on from PeptideChemSF — and this may be the naive question:
How would you tell the difference between that and the alternative explanation?